Assisi Loop

Targeted pulsed electromagnetic field therapy (TPEMF):
By emitting bursts of microcurrent electricity, the Assisi Loop creates a field which evenly penetrates both soft and hard body tissue around the target area. This electromagnetic field causes a chemical cascade, which activates the Nitric Oxide cycle. Nitric Oxide is a key molecule in healing for humans and animals.
https://www.assisianimalhealth.com/pet-owners/

Veterinary applications of pulsed electromagnetic field therapy
These PEMF devices differ significantly from other forms of electrotherapy such as transcutaneous electrical stimulation (TENS). In contrast to PEMF which uses an inductive antenna, TENS units require electrodes to be placed in contact with the skin. Because of this difference in the delivery of energy, TENS units drive current along the surface of the skin and cannot reach deeper tissue, whereas PEMF devices are able to deliver therapy to deeper targets (Claydon et al., 2011).” “Activation of these receptors [cell membrane adenosine receptor] by endogenous adenosine is associated with reductions in prostaglandins and inflammatory cytokines, again consistent with the published clinical findings of reduced pain and inflammation.
https://www.sciencedirect.com/science/article/pii/S003452881830208X
Authors: James Gaynor, Sean Hagberg, Blake T. Gurfein
Research in Veterinary Science, Volume 119, August 2018, Pages 1-8,

Evidence-Based Use of Pulsed Electromagnetic Field Therapy in Clinical Plastic Surgery
PEMF therapy has been used successfully in the management of postsurgical pain and edema, the treatment of chronic wounds, and in facilitating vasodilatation and angiogenesis.
https://doi.org/10.1016/j.asj.2009.02.001
Authors: Berish Strauch, Charles Herman, Richard Dabb, Louis J. Ignarro, Arthur A. Pilla
Published: Aesthetic Surgery Journal, Volume 29, Issue 2, March 2009, Pages 135–143

Effect of targeted PEMF therapy on canine post-operative hemilaminectomy: a double- blind, randomized, placebo-controlled clinical trial
Dogs receiving PEMF therapy following post-operative hemilaminectomy demonstrated improved wound scores at week 6 and reduced mean number of owner administered pain medications compared to sham therapy.
http://assisianimalhealth.com/research/veterinary-research/alvarez-lx-mccue-j-lam-nk-fox-p-gulce/
Authors: Alvarez LX1, McCue J1, Lam NK2, Fox P1, Gulce A3
Published: Journal of the American Animal Hospital Association.

The effect of electromagnetic fields on postoperative pain and locomotor recovery in dogs with acute, severe thoracolumbar intervertebral disc extrusion: a randomized placebo-controlled, prospective clinical trial
There was no difference in primary outcome or in secondary measures of gait, but proprioceptive placing was significantly better at 6 weeks and GFAP concentrations were significantly lower at 2 weeks in the PEMF group.
http://assisianimalhealth.com/research/veterinary-research/zidan-n-fenn-j-griffith-e-early-pj-mariani-cl-munana-kr-guevar-j-olby-n/
Authors: Zidan N, Fenn J, Griffith E, Early PJ, Mariani CL, Munana KR, Guevar J, Olby N.

2015 Pulsed Electromagnetic Fields Reduce Postoperative Interleukin-1β, Pain, and Inflammation: A Double-Blind, Placebo-Controlled Study in TRAM Flap Breast Reconstruction Patients
Pulsed electromagnetic field therapy significantly reduced postoperative pain, inflammation, and narcotic use following TRAM flap breast reconstruction, paralleling its effect in breast reduction patients.
http://assisianimalhealth.com/research/human-health-research/rohde-c-et-al-2015/
Authors: Rohde, C., et al.
Published: Plastic and Reconstructive Surgery, May, New York, NY